Leiden Institute of Chemistry (LIC)

In a multidisciplinary research line, in which organic and medicinal chemistry are combined with molecular biology and chemical biology, we aim to a) develop assays to determine the activity of proteins, and b) to design, synthesize and characterize small molecules that act as chemical tools to visualize and control protein activity. We use computational chemistry together with activity-based probes for compound profiling and optimization. In (inter)national collaborations with biologists and pharmacologists we test our molecules in preclinical models of disease. We aim to develop molecular tools to visualize and control the biosynthetic enzymes and the receptors of the endocannabinoids.

Principal investigators: 
Dr. Mario van der Stelt
Prof. dr. Hermen Overkleeft