Institute of Biology (IBL)

Our group carries out research on vertebrate developmental biology. We not only study fundamental questions of development and evolution, but we also use the zebrafish model system to study the effects of compounds including cannabinoids. In addition, we are interested in stress-related pathways, in particular the regulation of the secretion of the glucocorticoid hormone cortisol.

Within the Profile Programme we use zebrafish embryos and larvae to screen compounds that modulate (endo-)cannabinoid levels and synthetic (ant)agonists, for their  effects on behaviour. We will also study the development of various components of the endocannabinoid system in terms of gene expression. Mutant and transgenic fish will be used to probe the function of the endocannabinoid system. And finally, we will examine the relationship between the endocannabinoid system and the system that regulates the secretion of cortisol after stress.

Principal investigators: 
Prof. dr. Michael Richardson
Dr. Marcel Schaaf